Systematic review on effects of Ivermectin on COVID-19

Abstract

Objective: The purpose of the systematic review was to analyze the studies carried out on the effects of ivermectin on the mortality of patients diagnosed with COVID-19. Material and method: Cross-sectional, retrospective, analytical and observational research, the studies were obtained from the review of articles published in the main databases. A systematic review was previously carried out to finally show the results of the meta-analysis. Only 4 studies submitted to statistical analysis met the inclusion criteria required in this meta-analysis, which is the possibility of reproduction, the most specific possible, not being necessary to have a study in pairs. Results: The heterogeneity of the studies is low 18.2%, the Odds ratio in the fixed effects model is 0.42 (95% CI = 0.2640 - 0.6754) in a global sample of 660 patients belonging to 4 studies. Publication bias is not significant. Conclusions: The global OR found in the fixed effects model indicates that ivermectin administered to patients diagnosed with COVID-19 reduces the probability of death by up to 57.8%. No research analyzed in the meta-analysis is peer-reviewed.